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Toxicological evaluation of materials using in vitro assays
At The International Research Center in Critical Raw Materials for Advanced Industrial Technologies from the University of Burgos (UBU), we evaluate the human and environmental toxicity of materials applying a broad set of in vitro assays. For the study of human exposure, cell lines representative of different organs (lung, liver, intestine…) are used, together with 3D skin tissue models. For the evaluation of environmental exposures, several microorganisms such as the yeast Saccharomyces cerevisiae, or the bacteria Vibrio fischeri and Pseudomonas putida are used. The parameters to measure the toxicity include viability, ROS production, irritation, interleukin release, growth curves depending on the organism applied in the tests.
Deliverables
Specifications and Deliverables
A report describing the results obtained in the different experiments carried out to evaluate the toxicity of the materials of interest will be provided to the costumers. Together with the results and conclusions, the protocols applied to perform the experiments will be also specified.
Value Proposition
To assess the toxicity of the materials that is unknown by the provider. Toxicological studies are essential to determine the human and environmental risk of materiasl, including the new developed ones before they can enter the market. Moreover, the application of in vitro test systems present several advantages: use of simple biological models that bypass ethical concerns, cost-effective and easy to apply approaches and great control over the variables under study.
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